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Concomitant utilization of oxycodone HCl with CYP3A4 inducers or discontinuation of the CYP3A4 inhibitor could decrease oxycodone plasma concentrations, lessen opioid efficacy or, maybe, result in a withdrawal syndrome inside of a patient who had produced Actual physical dependence to oxycodone.Cytochrome P450 3A4 Conversation. The concomitant usag